Welcome to the Gene Sharing Network Browser!

This interactive webpage is designed to help you explore the gene sharing networks in Arabidopsis:

In these tissue networks, nodes represent tissues and the size of each node is proportional to the number of leptokurtic genes associated with that node. Tissue pairs in the networks are connected by an edge if they share a significant number of commonly associated leptokurtic genes, with significance defined by tissue similarity scores. Nodes are color coded according to their tissue types, and edges are color coded according to the tissue similarity score: a dark blue edge represents high similarity between two tissues, an aqua edge represents intermediate similarity between two tissues, and a light green edge represents lower similarity between two tissues.

You can choose to view two types of networks: the high threshold network provides a global view of the Arabidopsis gene sharing network by using higher thresholds: 1e-09 as the FDR threshold of kurtosis (Q<1e-09), 10 as the relative expression level threshold (Z = 10), and 20 as the tissue similarity score threshold (S = 20). The low threshold network displays just the first neighbor network for the tissue selected in the lower box; it includes all edges that pass the following thresholds: Q<0.005, Z = 3 and S = 40. See manuscript for definitions of the thresholds used for each type of network.

First 'Choose a network:' then click on 'Draw Network' to show the tissue network. Then you can:

Search a gene by clicking on the 'Search Genes' button.
Select a gene from 'Gene List' and click on 'Show Annotation'.
Click on nodes or edges to focus on a specific tissue or tissue pairs.
Click on 'Show Tissue List' to find first neighbor tissues.

See the Getting started page for instructions on using this website.

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